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KMID : 1149220090170020085
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.85 ~ p.98
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Synergic Effect of Methanol extracts of Schizandrae Fructus and Mume Fructus on Experimental Mouse Colitis Induced by Dextran Sulfate Sodium
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Jang Seon-Il
Mok Ji-Ye
Choi Hyo-Jung
Jeon In-Hwa
Lee Kang-Soo
Yun Young-Gab
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Abstract
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The fruits of Schisandra chinensis and Prunus mume have been traditionally used in the Oriental countries as an astringent against diarrhea and abdominal pain, a protectant for liver disease, an antimicrobial, and a blood tonic. However, little is known about the extract of Schizandrae Fructus and Mume Fructus (SMF-Ex) on dextran-sulfate sodium (DSS)-induced colitis in mice. In this study, we investigated the protective effects of SMF-Ex on DSS-induced colitis in mice. An experimental colitis was induced by daily treatment with 5% DSS. SMF-Ex was orally administrated the single dose (80 mg/kg, body weight/day) for 7 days with one time per day. SMF-Ex reduced significantly clinical sign of DSS-induced colitis, including body weight loss, shorten colon length, increased disease activity index (DAI), and histological colon injury. SMF-Ex also inhibited significantly nitric oxide (NO) and prostaglandine E2 (PGE2) productions in DSS-induced colitis mice. Futhermore, SMF-Ex increased significantly an superoxide anion (SOD), catalase, and glutathione peroxidase (Gpx) activity of the colon tissue in DSS-induced colitis mice. These results suggest that SMF-Ex administration could reduce significantly the clinical signs and inflammatory mediators, and increase antioxidant activity in DSS-induced colitis model mice and is a good candidate for further evaluation as an effective anti-ulcerative agent.
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KEYWORD
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Schizandrae Fructus and Mume Fructus (SMF-Ex), Ulcerative colitis, Antioxidant activity, Dextran sulfate sodium (DSS)
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